Fenbendazole For Cancer
Fenbendazole for cancer gained traction after Joe Tippens claimed it cured his stage four colon cancer. However, it’s important to note that he was enrolled in a clinical trial and received other conventional treatments at the time.
This anthelmintic drug works by activating p53-dependent apoptosis and ferroptosis-augmented apoptosis in CRC cells. It also prevents glucose uptake by cancer cells, which reduces their energy supply.
It kills parasites
Unlike traditional cancer drugs, which target tumor cells, fenbendazole targets parasites that live inside the cell. It does this by disrupting the growth of microtubules, which give shape to all cells. This is similar to how anti-malaria medications work. The difference is that these drugs don’t cause side effects and can be taken for a long time.
In the lab, fenbendazole showed promise in inhibiting cell cycle progression and inducing death in colorectal cancer cells and patient-derived colon cancer organoids. However, the results were not statistically significant. In addition, the drug’s ability to induce ferroptosis was compromised by the inhibition of p53 and decreased expression of glutathione peroxidase 4 (GPX4).
The research was published in the journal Nature Cell Biology. It also noted that fenbendazole could be combined with other chemotherapy treatments to improve their efficacy. The research is promising, but further clinical trials are needed to determine whether fenbendazole is an effective treatment for cancer in humans.
Despite the anecdotal claims, there is no evidence that fenbendazole can cure cancer in people. The drug has not been tested in petri dishes or mice, and it hasn’t gone through any human clinical trials. A specialist cancer information nurse at Cancer Research UK said there’s no evidence that fenbendazole is a cancer cure. It can, however, help patients feel more comfortable while receiving other conventional cancer treatments.
It kills cancer cells
While text book depictions of cells often portray various cellular components floating in amorphous bags of liquid, the reality is that they establish shape and structure through a protein scaffold called the cytoskeleton. This framework is largely composed of microtubules. Fenbendazole interferes with the formation of these structures, causing apoptosis in cancer cells. It also inhibits glucose uptake, a process that fuels tumor growth.
The researchers conducted experiments in which they injected human colorectal cancer cells into mice and monitored the tumors’ growth. The results showed that fenbendazole killed cancer cells in a manner similar to other established cancer treatments, such as ionizing radiation and chemotherapy. They found that the drug caused apoptosis through multiple pathways, including moderate microtubule disruption, p53 stabilization, and interference with glucose metabolism.
These findings suggest that fenbendazole could be a promising candidate for treating cancer. This is particularly true given that its toxicity to normal cells is minimal and that it interacts with many different targets in the cell. This could potentially lead to improved efficacy and circumvent the development of resistance that commonly hamparse single-target cancer drugs.
In another experiment, the researchers compared the growth of EMT6 tumors in BALB/c mice treated with three daily i.p. injections of fenbendazole alone or in combination with 10 Gy of ionizing radiation. The researchers rigorously analyzed tumor growth, calculating the time it took for each tumor to grow from its initial volume to four times that volume. They found that fenbendazole had no effect on the growth of unirradiated tumors, but was significantly effective when combined with x-rays.
It prevents recurrence
Fenbendazole is an antiparasitic drug used in the treatment of parasitic worms in animals. It is also being studied as a cancer treatment. It works by inhibiting the growth of cancer cells and by killing them. It is available in oral granules or as a liquid suspension. It can be taken by mouth seven days a week and is well tolerated by most people. It is recommended to take 222 mg of fenbendazole per day. This dose is equivalent to a small pill. It is important to take the medication with food to prevent gastrointestinal upset.
In addition to its effects on worms, fenbendazole is known to affect cell signaling and cause oxidative stress. This effect may be attributed to its inhibition of glucose uptake in cancer cells. To test this, researchers treated two colorectal cancer cells with fenbendazole. They found that the drug caused apoptosis through mitochondrial injury and caspase-3-poly (ADP-ribose) polymerase (PARP) pathways. In addition, it suppressed the expression of the autophagy protein Beclin-1 and the activity of GPX4.
The research team also reported that fenbendazole caused the phosphorylation of p53 in 5-fluorouracil-resistant SNU-C5 cells. This suggests that fenbendazole could be an alternative treatment for genitourinary malignancies in patients who are resistant to conventional chemotherapy. Moreover, fenbendazole has multiple targets and is more effective than single-target drugs. This makes it more likely to evade resistance.
While there are studies that show fenbendazole is effective in cancer cells in petri dishes and mice, there’s no evidence that it’s effective in humans. And while some preclinical studies are examining this drug as a possible cancer treatment, there’s insufficient evidence that it’s safe for human use.
The claim that fenbendazole cures cancer is based on anecdotal evidence of a patient who was reportedly cured after using fenbendazole. However, the anecdote is misleading because it doesn’t include other factors that may have contributed to the patient’s remission, such as conventional cancer treatments.
This drug is available as oral granules or liquid suspension and should be taken with food to prevent gastrointestinal upset. It is recommended to take 222 mg of the medication per day, seven days a week. If you are not sure how to take the medicine, consult your doctor.
In addition to killing parasites, fenbendazole also kills cancer cells. It works by stopping the growth of microtubules, which give structure to all cells. In a recent study, researchers found that fenbendazole suppressed the growth of colorectal cancer cells in a lab dish. It also caused apoptosis in the tumors of mice. The results suggest that fenbendazole is a promising candidate for a new anti-cancer therapy. In a clinical trial, my team at City of Hope compared the effects of fenbendazole to that of a watchful homeowner. The homeowner shuts off the water so it can’t overflow and damage other parts of the house.